On account of studying the feasibility of the production instant cereal beverage powders admixed with mulberry leaves by extrusion process to satisfy the demands of increasingly health-conscious consumers,a box-behnken design of the response surface methodology (RSM) was employed to investigate the interaction of operating conditions at varying screw speed (300,350 and 400 rpm),mulberry content (5,10 and 15%) and feed moisture (15,17 and 19%) on the physical and antioxidant property of product.Data were modelled by multiple regression analysis and the coefficients of regression equation were obtained with high correlation coefficient indicating for best fit model.