Subunits containing carbonrings、 nitrogen heterocycles and spirocyclic structures are common in biologically active molecules.Pyrazolone derivatives,representing an important class of five membered-ring lactams,have exhibited a variety of applications as pharmaceutical agents,synthetic scaffolds in medicinal and synthetic chemistry.Especially,pyrazolin-5-ones derivatives have been well known as analgesic and antipyretic agents.As a consequence,many diverse methods to access structurally diverse heterocyclic spirooxindoles have been developed during the past few years.