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肺动脉高压(PAH)以肺血管重构为显著特征,其中肺动脉平滑肌细胞异常增殖是构成肺动脉血管重构的主要病理基础.TRPCs是PASMCs细胞膜上的非选择性阳离子通道超家族,对维持细胞内外钙离子浓度具有重要作用,抑制其表达可抑制肺血管重构,缓解肺动脉高压的发生.
miR-135a-5p抑制肺动脉平滑肌细胞中TRPC1的表达降低大鼠肺动脉高压
【摘 要】
：
肺动脉高压(PAH)以肺血管重构为显著特征,其中肺动脉平滑肌细胞异常增殖是构成肺动脉血管重构的主要病理基础.TRPCs是PASMCs细胞膜上的非选择性阳离子通道超家族,对维持细胞内外钙离子浓度具有重要作用,抑制其表达可抑制肺血管重构,缓解肺动脉高压的发生.
【机 构】
：
第三军医大学药物研究所,重庆400038
【出 处】
：
2016年全国抗炎免疫药理学术会议
【发表日期】
：
2016年11期
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