【摘 要】
：
Several complex molecular events are involved in tumorigenesis of hepatocellular carcinoma (HCC).The interactions of these molecules may constitute the HCC imbalanced network.Gansui Banxia Tang (GSBXT
【机 构】
：
China Academy of Chinese Medical Sciences, Beijing
【出 处】
：
第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会
论文部分内容阅读
Several complex molecular events are involved in tumorigenesis of hepatocellular carcinoma (HCC).The interactions of these molecules may constitute the HCC imbalanced network.Gansui Banxia Tang (GSBXT), as a classic Chinese herbal formula, is a popular complementary and alternative medicine modality for treating HCC.In order to investigate the therapeutic effects and the pharmacological mechanisms of GSBXT on reversing HCC imbalanced network, we in the current study developed a comprehensive systems approach of integrating disease-specific, and drug-specific networks, and successfully revealed the relationships of the ingredients in GSBXT with their putative targets, and with HCC significant molecules and HCC related pathway systems for the first time.Meanwhile, further experimental validation also demonstrated the preventive effects of GSBXT on tumor growth in mice and its regulatory effects on potential targets.
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