Adoptive immunotherapy is a highly effective approach for cancer treatment.Several potential adoptive immunotherapies have high(though reversible)toxicities with disappointing results.Polyhydroxylated fullerenols have been demonstrated as promising antitumor drugs with low toxicities.In this study,we investigate whether polyhydroxylated fullerenols contribute to cancer immunotherapy by regulating macrophages.Our results show that fullerenols treatment enhances mitochondrial metabolism,phagocytosis and cytokine secretion.Moreover,activated macrophages inhibit the growth of several cancer cell types.It is likely that this inhibition is dependent on an NF-κB-mediated release of multiple cytokines.