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5. Histone methylation and acethylation contribute to rifampin-mediated induction of CYP3A4 through the

Histone methylation and acethylation contribute to rifampin-mediated induction of CYP3A4 through the

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：andykiteelxu

【摘 要】

：

OBJECTIVE CYP3A4 is one of the major drug-metabolizing enzymes in humans and is responsible for the metabolism of over 50% of the clinically used drugs.Many drugs have been proved to induce the expres

【作 者】

：

YAN Liang ZHANG Li-rong 

【机 构】

：

Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001

【出 处】

：

中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛

【发表日期】

：

2016年11期

【关键词】

：

CYP3A4 induction histone modification PXR 

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　　OBJECTIVE CYP3A4 is one of the major drug-metabolizing enzymes in humans and is responsible for the metabolism of over 50% of the clinically used drugs.Many drugs have been proved to induce the expression of CYP3A4, which usually causes drug-drug interactions and adverse reactions.

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