【摘 要】
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Summary To investigate the inhibition effect and mechanism of salvia miltiorrhiza on the muscular fibrosis in the rat after the sciatic nerve injure.Salvia miltiorrhiza was injected into the rat dener
【机 构】
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Union Hospital,Tongji Medical College,Huazhong University of Science and Technology
【出 处】
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中国康复医学会修复重建外科专业委员会第19次全国学术交流会
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Summary To investigate the inhibition effect and mechanism of salvia miltiorrhiza on the muscular fibrosis in the rat after the sciatic nerve injure.Salvia miltiorrhiza was injected into the rat denervated gastrocnemius muscle.The expression and synthesis of collagen were detected.The rat skeletal muscle-derived stem cells(MDSCs)were obtained by using preplate technique and were co-cultured with salvia miltiorrhiza and TGF-β1.The expression and synthesis of Smad3,Smad7,COLⅠand COL Ⅲ were detected by mmunocytochemistry,RT-PCR and Western-blot analysis.
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