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In order to discover new potential natural-product-based crop protection agents,we synthesized three new matrine derivatives,13-cyclohexylaminomatrine(M-Cyc-Mat),13-cyclohexylaminothiocarbonylthiomatrine(S-Cyc-Mat),13-(4-methyl)cyclohexyla minothiocarbonylthiomatrine(S-M-Cyc-Mat),by introducing different active groups to C-13 position of matrine,a biorenewable quinolizidine alkaloid isolated from Sophora flavescens.