Objective: To evaluate the feasibility and safety of pure laparoscopic radical nephrectomy and thrombectomy for renal tumor patients with venous tumor thrombus.Methods: From Jan 2013 to Dec 2014,records of patients with renal tumor and venous thrombus treated in our institute were retrospectively reviewed.Thirteen patients underwent pure laparoscopic radical nephrectomy and thrombectomy,including seven patients with renal vein(RV)thrombus and six patients with inferior vena cava(IVC)thrombus.Retroperitoneal approach was undertaken for RV thrombus patients,while transperitoneal approach or combined retroperitoneal and transperitoneal approach for IVC thrombus patients.During the combined approach surgery,renal artery and lumbar vein were controlled through retroperitoneal approach,and the thrombectomy procedure was completed through transperitoneal approach.Results: There were nine male patients and four female patients.All patients ranged from 30 to 78 years old(median,55 years old).Seven patients were diagnosed by routine medical examination,while six patients had clinical symptoms,including four with gross hematuria and two with flank pain.All patients underwent operations successfully.Operation time ranged from 84 to 456 minutes(median 195 minutes).The blood loss ranged from 50 to 150 mL(median,50 mL)for RV tumor thrombus patients,and 100 to 2,500 mL(median,325 mL)for IVC tumor thrombus patients.All patients recovered well after surgery without major complications.With the postoperative pathological examination,the average tumor maximum diameter was 7.9±2.5 cm.Eleven cases of clear cell renal cell carcinoma,one case of chromophobe renal cell carcinoma and one case of renal metastatic osteosarcoma were showed in our study.Median follow-up time was 13 months(2-22 months).No decease was observed at the last follow-up.Three patients experienced distant metastasis after surgery,including two patients with multiple pulmonary metastases and one patient with lumbar vertebral metastasis.Conclusions: Pure laparoscopic radical nephrectomy and thrombectomy is feasible and safe,with promising oncological prognosis.Combined retroperitoneal and transperitoneal procedures can take both the advantages of these two approaches and simplify operative manipulations.