Antibacterial Activity of Antisense Peptide-Peptide Nucleic Acid Conjugates Against NDM-1 Klebsiella

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：ankeng

【摘要】

：

　　Worldwide spread of Klebsiella pneumoniae with carbapenemase New Delhi metallo-β-lactamase 1(NDM-1)presents major challenge to public health due to limited

【作者】

：

Hui Bai Lijie Chen Zheng Hou Ying Zhou Xiaoxing Luo Shengqi Wang

【机构】

：

DepartmentofBiotechnology,BeijingInstituteofRadiationMedicine,Beijing,100850,China;DepartmentofPharm

【出处】

：

第五届中国小核酸技术与应用学术会议

【发表日期】

：

2015年9期

【关键词】

：

Antisense oligonucleotides therapy New Delhi metallo-beta-lactamase 1 Klebsiella

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　　Worldwide spread of Klebsiella pneumoniae with carbapenemase New Delhi metallo-β-lactamase 1(NDM-1)presents major challenge to public health due to limited effective antimicrobials.PPNA06 is a cell penetrating peptide(CPP,(RXR)4XB)conjugated antisense peptide nucleic acids(PNAs)targeting the start codon region of bacterial essential gene rpoD.

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Antibacterial Activity of Antisense Peptide-Peptide Nucleic Acid Conjugates Against NDM-1 Klebsiella

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