Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the

来源 :2016年全国抗炎免疫药理学术会议 | 被引量 : 0次 | 上传用户：leec208

【摘要】

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【作者】

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Xueqing Xu Bei Zhang Shilong Yang Su An Jose'M.C.Ribeiro John F.Andersen

【机构】

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Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southe

【出处】

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2016年全国抗炎免疫药理学术会议

【发表日期】

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2016年11期

【关键词】

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Salivary gland crystal structure Xenopsylla cheopis NaV1.5

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Naturally occurring toxins have been invaluable tools for the study of structural andfunctional relationships of voltage-gated sodium channels.Few studies have been made of potential channel-modulating substances from blood-feeding arthropods.He we describe the characterization FS50, a salivary protein from the flea, Xenopsylla cheopis, that exhibits an inhibitory activity against the NaV1.5 channel with an IC50 of 1.58 μtM.

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Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the

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