TLR9-INDUCED MIR-155 DECREASE EXPRESSION OF CD1D ON B CELLS IN SLE

来源 :The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) | 被引量 : 0次 | 上传用户:jessicazrz
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
B cells present lipid antigens to CDld-restricted invariant natural killer T (iNKT) cells to maintain autoimmune tolerance, and this process is disrupted in systemic lupus erythematosus (SLE).Inflammation may inhibit CD l d expression to exacerbate the pathology of lupus.However, how inflammation regulates CDld expression on B cells is unclear in SLE.Here we showed that the surface expression of CDld on splenic B cells from MRL-lpr/lpr mice at 24 weeks was decreased compared with that of B cells from healthy controls.
其他文献
T-cell acute lymphoblast leukemia (T-ALL) is usually a highly aggressive non-Hodgkins lymphoma and most patients die within one year of diagnosis.Thus, it is urgent to find an effective way of cure.In
会议
There is growing epidemiological evidence that vitamin B6 has potential anti-inflammatory activity in a variety of inflammatory diseases, and patients with inflammation had significantly lower blood l
会议
Germinal center (GC) reaction is crucial in adaptive immune responses.The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6.Although gene expression is cri
会议
Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA).The current study was undertaken to investigate whether a proliferation-inducing liga
Initial exposure to lipopolysaccharide (LPS) induces endotoxin tolerance, a transient tolerance to subsequent LPS challenge.Negative regulators induced by initial LPS has been proposed to play key rol
会议
Background and Aim: Interact with IL23R and IL12Rβ1, IL-23 plays an important role in chronic inflammation, autoimmune diseases, and tumors by shaping the development of Th1/Th17 cells.IL17A is consid
Objective: To investigate the characteristics and potential mechanism of DCs pulsed by liver X receptor, T0901317, by comparison with natural tolerant DCs (CD4+ Dcs).Materials and methods: Bone marrow
会议
Background: Patients suffering from Graves disease (GD) exhibit thyroid enlargement on account of excessive activation and proliferation of thyroid epithelial cells.Precise molecules involved and the
Triptolide (TP), a diterpenoid triepoxide from Tripterygium wilfordii Hook F, is widely used to treat autoimmune and inflammatory diseases, especially rheumatoid arthritis (RA).However, the detailed m
会议
Chemerin is highly expressed in hepatocytes, and recently suggested to regulate tissue inflammation.Hepatocellular carcinoma (HCC) is associated with Inflammation and immunosuppression, which is chara
会议