【摘 要】
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BACKGROUND/AIMS: Colorectal cancer with liver metastasis is the most commonly advanced stage.We proposed that patients with solitary liver metastasis should be classified as a distinct subdivision wit
【机 构】
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Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 X
【出 处】
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第十二届全国大肠癌学术会议暨江苏省第九届腹腔镜外科会议
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BACKGROUND/AIMS: Colorectal cancer with liver metastasis is the most commonly advanced stage.We proposed that patients with solitary liver metastasis should be classified as a distinct subdivision with better survival than patients with multiple liver metastases.METHODS: We collected 445 patients diagnosed with only liver metastasis from colorectal cancer, and divided them into two groups: solitary liver metastasis group and multiple liver metastases group.The corresponding colorectal cancer-specific survival data were also obtained.We used Kaplan-Meier method, Cox regression analysis to estimate the relationship between the number of liver metastasis and prognosis of patients.RESULTS: The median cancer-specific survival was 21.0 months in solitary liver metastasis group, as compared with 14.0 months in multiple liver metastases group.Patients in solitary liver metastasis group had better 5-year cancer-specific survival than those in multiple liver metastases group based on Kaplan-Meier method.Results in both univariate and multivariate analysis also suggested that number of liver metastasis was an independent prognostic factor for survival outcome.In addition, this finding was also confirmed by further analysis in 24 subgroups which were confined by demographic and clinicopathologic characteristics.CONCLUSIONS: Colorectal cancer with solitary liver metastasis was found to be a distinct subdivision with a favorable prognosis.
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