【摘 要】
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Transition-metal-catalyzed cycloaddition reactions are the commonly-used methods for the construction of bridge-containing carbocyclic and heterocyclic structures, which exist in numerous natural prod
【机 构】
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College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China
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Transition-metal-catalyzed cycloaddition reactions are the commonly-used methods for the construction of bridge-containing carbocyclic and heterocyclic structures, which exist in numerous natural products and active pharmaceutical ingredients.[1] Tropone and the related compounds in troponoid family have been recognized as valuable synthons of natural products and suitable partners in higher order cycloadditions since the identification of tropolone moiety as a key unit of alkaloids.[2] In conjunction with our continuing efforts in imino ester chemistry,[3] we envision that the in situ generated azomethine ylides from imino esters could be employed as the hetero three-atom synthons in the cycloaddition with tropone (6-πdipolarophile).
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