【摘 要】
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The respective advantages of porcine bone hydroxyapatite (PBHA) and chitosan (CS) were combinated together, Chinese medicine Drynariae Rhizoma (DR) was introduced into bone repair materials for the pu
【机 构】
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Provincial Key Laboratory of Biomaterials, Jiamusi University, Jiamusi, 154007, China
【出 处】
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第十一届全国表面工程大会暨第八届全国青年表面工程学术会议
论文部分内容阅读
The respective advantages of porcine bone hydroxyapatite (PBHA) and chitosan (CS) were combinated together, Chinese medicine Drynariae Rhizoma (DR) was introduced into bone repair materials for the purpose of good osteoindaction, DR-PBHA-CS porous composite biomaterials was fabricated by the Vacuum freeze drying method. In order to improve the strength of the scaffold material, Porcine bone hydroxyapatite surface and CS were modified before the preparation of the DR-PBHA-CS porous composite biomaterials. PBHA was modified with the coupling agents KH-570(PBHA[K]). CS was modified with the coupling agents NDZ-311(CS[N]). The compressive strength of the porous biomaterials and the porosity was tested. The microscopic morphology and components of the biomaterials were analyzed by SEM, and Energy Spectra, Respectively biological activity of the porous biomaterials were studied by Simulated Body Fluid (SBF) and rabbit in vivo implantation. Results show that: The compressive strength of the porous biomaterials is enhanced by CS and PBHA modifying with the NDZ-311 and KH-570 coupling agents, the compressive strength is in the range of 5.6~0.1MPa. The pore structure of the porous biomaterials is cellar-shaped, PBHA distributed homogeneously in the pore walls. With an increasing content of CS, the porosity of the porous biomaterials gradually increase and the compressive strength gradually decrease. Bone-like apatite form on the surface of the materials after immersion in SBF. The introduction of the DR speeds up the formation and maturity of new bone by histological observation, with bone density of bone defect region increases gradually, which shortens the osteogenic period. Surface modification has no effect on the biological properties of the DR-PBHA-CS porous composite biomaterials.
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