Objective: Bone formation by osteoblasts and bone re sorption by osteoclasts contributes to the balance of bone remodelling.Most pathologic bone diseases are due to excess osteoclastic activity, leadi
Objective: To determine the effect of iguratimod, a novel DMARD, on bleomycin-induced lung fibrosis and describe the underlying mechanisms.Methods: Mice were anaesthetized and then intratracheally inj
Aims: Insulin resistance, a hallmark of type 2 diabetes, is associated with obesity.Obesity gives rise to a state of chronic, low-grade inflammation that contributes to insulin resistance.Obese adipos
Regulatory B cells (Breg) are immunosuppressive cells that protect immune responses that can result in uncontrolled inflammation.Multiple studies demonstrated that IL-10 is not just a maker for Breg i
Background: SIRT1, a highly conserved NAD+-dependent protein deacetylase, plays a pivotal role in caloric restriction on lifespan and metabolic pathways as well as in the regulation of pathogenesis an
Aim: Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, has a median survival of 3 to 5 years from diagnosis, but its etiology remains unknown.
Objective: The aim of the present review is to analyse the involvement of the matrix metalloproteinases (MMPs) and the inflammatory pathway in the physiopathological development of pulmonary fibrosis.