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5. FFPM,a PDE4 inhibitor,recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CREB/BDNF

FFPM,a PDE4 inhibitor,recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CREB/BDNF

来源 :第十七届全国神经精神药理学学术会议 | 被引量 : 0次 | 上传用户：xcnyy_007

【摘 要】

：

OBJECTIVE In this study,we investigated the effect of FFPM,a novel PDE4 inhibitor,on learning and memory deficits as well as the underlying mechanism in APP/PS1 transgenic mouse model of Alzheimer dis

【作 者】

：

GUO Hai-biao XU Jiang-ping 

【机 构】

：

Group of Neuropharmacology and New Drug Discovery,School of Pharmaceutical Sciences,Southern Medical

【出 处】

：

第十七届全国神经精神药理学学术会议

【发表日期】

：

2016年5期

【关键词】

：

FFPM cognition Alzheimer disease phosphodiesterase-4 

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　　OBJECTIVE In this study,we investigated the effect of FFPM,a novel PDE4 inhibitor,on learning and memory deficits as well as the underlying mechanism in APP/PS1 transgenic mouse model of Alzheimer disease(AD).METHODS UPLC-MS/MS was used for pharmacokinetic study.

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