The aberrant carbohydrate structure expressing on the surface of cancer cells known as tumor-associated carbohydrate antigens(TACAs),provide a target for cancer vaccines.
The methyltransferase SETD7/9(SETD7)is an important therapeutic target in cancer.(R)-PFI-2 had a high affinity to hSETD7 with nano-molar IC50 values,while(S)-PFI-2 showed 500-fold less active in IC50
As an important target for potential herbicides,protoporphyrinogen oxidase(PPO,EC 1.3.3.4)is the penultimate enzyme in the biosynthesis of chlorophyll and heme,which catalyzes protoporphyrinogen Ⅸ to
Gene therapy is a promising strategy for the treatment of many gene related diseases.A safe and efficient gene delivery vector is always the first key step for the development of gene medicine.
Synthetic small interfering RNAs(siRNAs)can inhibit expression of disease-causing genes through post-transcriptional gene silencing mediated by the endogenous RNA interference(RNAi)pathway[1].