A simple,rapid,sensitive and effective method,hollow fiber liquid phase microextraction (HFLPME) combining with high performance liquid chromatography ( HPLC) has been developed and introduced for the simultaneous preconcentration and quanti.cation of trace amounts of lignans,which are schisandrolA,schisantherinA,schizandrinA,schizandrinB,from traditional Chinese medicine (TCM) Schisandra chinensis in rat biological.uids.