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  5. A sub-pathway-based approach for identifying drug response principal network

A sub-pathway-based approach for identifying drug response principal network

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：c1133186
【摘 要】
：
Motivation: The high redundancy of and high degree of cross-talk between biological pathways hint that a sub-pathway may respond more effectively or sensitively than the whole pathway.However, few cur
【作 者】
：
陈秀杰 陈胜 李霞 徐建凯 黄邦清 李晋 马玲 贾晓东 边秀森 谭福建 刘磊 
【机 构】
：
生物信息学院,哈尔滨医科大学,哈尔滨 生物信息学院,哈尔滨医科大学,哈尔滨;药理教研室,哈尔滨医科
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
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　　Motivation: The high redundancy of and high degree of cross-talk between biological pathways hint that a sub-pathway may respond more effectively or sensitively than the whole pathway.However, few current pathway enrichment analysis methods account for the sub-pathways or structures of the tested pathways.We present a sub-pathway-based enrichment approach for identifying a drug response principal network, which takes into consideration the quantitative structures of the pathways.
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