Background:In the treatment of the submucosal tumors (SMTs) of upper gastrointestinal, the endoscopic submucosal tunnel dissection (ESTD) can maintain the mucosal integrity while achieving en bloc resection.In this study, we aim to evaluate the efficacy and safety of the ESTD for SMTs of the esophagogastric junction (EGJ).Methods:Between June 2011 and November 2013, 30 consecutive patients with 30 SMTs located between 5 cm above or below the EGJ were included.The submucosal tunnel was created starting 5 cm proximal to the lesion.After the SMTs were removed, the entrance of tunnel were closed using titanium clips.The clinical outcome,complication, en bloc resection, hospital stays and cost were evaluated.Results:On EUS, 93.3% (28/30) SMTs were located in the muscularis propria layer, and 66.7% (20/30) were hypoechoic.The average length the SMTs was 22.3 mm (range 6-80 mm).The mean time of ESTD procedure was 52.5 min (range 18-150 min).The en bloc resection rate was 93.3% (28/30).Histologically, 5 GISTs and 25 leiomyoma were identified.There were 2 (6.7%) and 8 (26.7%) patients occurred complication during and after the ESTD procedure.The mean of hospital stays were 9.0 days (range 5-21 days), and the hospitalization cost were 27762.3 CNY (range 15409-55353 CNY).Conclusions:Our results suggested the ESTD was an effective and a relatively safe endoscopic technique for the treatment of SMTs of the EGJ.The efficacy and safety of the ESTD, compared to other conventional approaches, need be further evaluated.