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The objective of this study was to explore the association of TLR4 rs1927911 and TLR2 rs5743708 with atherosclerotic cerebral infarction (ACI) and their effects on blood pressure, fasting blood glucose, and blood lipids in the Han population of Hunan Province.TLR4 rs1927911 and TLR2 rs5743708 were detected by PCR and restriction fragment length polymorphism in 170 patients with ACI and 149 healthy controls.Our results indicated that the genotype and allele frequencies of TLR4 rs1927911 were significantly different between ACI patients and controls, whereas those of TLR2 rs5743708 were not significantly different between the two groups.For TLR4 rs1927911 and TLR2 rs5743708, blood pressure, fasting blood sugar and serum lipid levels were not significantly different among different genotypes in the ACI and control groups.