Roles of protein tyrosine phosphatase SHP2 in regulating the integrity of vascular endothelium

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:welson926
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Endothelial cells are the inner mono-layer cells of the blood vessels, playing critical roles toseparate blood from underlying tissues.Endothelial cells form a dynamic and selective permeabilitybarrier, which is important for interstitial homeostasis, inflammatory, angiogenesisand vascular remodeling.
其他文献
Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor, and its clinicalapplication (Vorinostat) has been demonstrated to treat nonsmall cell lung cancer(NSCLS).Nevertheless, the im
Cystathionine-β-synthase Redoxr egulationCystathionine β-synthase (CBS) is the first rate-limiting enzyme in the transsulfurationpathway and by utilizing homocysteine produces the cysteine, a precurso
Lysine acetylation is emerging as a ubiquitous and conserved posttranslational modificationin living cells.While the role of lysine acetylation in regulating primary metabolism iswell-established, its
Background: Ubiquitin-proteasome pathway plays indispensable roles in many biologicalprocesses.The protein ubiquitination is catalyzed by three enzymes, the E1 ubiquitin activatingenzyme, the E2 ubiqu
In previous studies, iron has been shown to play a significant role in the formation of freeradicals which contributed to oxidative stress, resulting in cell damage.Damage to culturedhepatocytes was p
Ovarian cryopreservation by vitrification is a very effective method for preserving femalesfertility during chemotherapy and radiotherapy, and studying of the gene expressionduring ovarian cryopreserv
Despite of the progress in identifying many Lys acetylation (Kac) proteins, Kac substratesfor Kac-regulatory enzymes remain largely unknown, presenting a major knowledge gap inKac biology.
This study elucidated the role of CaN-NFAT signaling and neurotrophins on thetransformation of myosin heavy chain isoforms in the rat soleus muscle fiber following aerobicexercise training.To do so, w
Uniblue A and its derivatives are a class of low-cost dyes that can be used to covalently labelproteins.The efficiency of staining, in companion with the subsequent detection methods,is critical for t
Yeast Hifl, a homologue of human nuclear autoantigenic sperm protein (NASP), is a histonechaperone that involved in various protein complexes modifying histones during telomericsilencing and chromatin