Many genetic mouse models of Huntingtons disease(HD)have been created but none fully recapitulate the cardinal phenotypes of HD.Transgenic mice expressing exon 1 of huntingtin show a severe phenotype
The cholinergic Nucleus Basalis of Meynert(NBM),which is important for memory functions,shows neuronal activation(up-phase)during the early stages of Alzheimers disease(AD)and neurodegeneration(down-p
The inflammasomes,which mediate the activation of caspase-1 and maturation of IL-1β and IL-18,has been unambiguously verified to participate in many diseases,such as lung diseases,infectious diseases
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves cleavage of amyloid precursor protein(APP)by γ-secretase,a protease known to cleav