Background: Crohns disease is a type of chronic inflammatory bowel disease of which molecular pathogenesis still unknown[1].Some studies verified that mental disorders may cause gastrointestinal diseases,for example,children with autism have an increased incidence of gastrointestinal symptoms compared with matched control subjects in a population-based sample[2].Alzheimer disease (AD) is primarily a disease of aging,with an incidence that doubles every 5 years[3].