【摘 要】
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Objective: This study aimed to evaluate the risk of breast cancer associated with beta-blockers in Chinese population.Methods:A population-based case-control study of women with hypertensive and ages
【机 构】
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Department of Radiation Oncology, Tainan Municipal An-Nan Hospital-China medical university
【出 处】
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第九届泛珠江区域放射肿瘤学学术大会暨肿瘤放射治疗多中心协作研讨会、重庆市医学会放射肿瘤治疗学专业委员会2014年会
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Objective: This study aimed to evaluate the risk of breast cancer associated with beta-blockers in Chinese population.Methods:A population-based case-control study of women with hypertensive and ages over 18 years was conducted by using the Taiwan National Health Insurance Research Database between 1 January 2006 and 31 December 2011.The responses of 6463 women who were diagnosed with invasive breast carcinoma were compared with the responses of 18987 women in a control group.Associations between use of different beta-blockers and breast cancer incidencewere evaluated using logistic regression.Results: Overall, there was no statistically significant association between ever use of beta blockers in adjusted model (OR: 0.64;95%CI: 0.57-0.71).However, higher risk of breast cancer is likely to be associated with beta-blockers (p =<0.0001 for trend).Conclusion: This is the first study to observe that long-term current use of beta blockers is associated with breast cancer risk.Further comprehensive research is needed to confirm this finding in Chinese population.
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