丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路(Ras/Raf/MEK/ERK)是细胞内非常重要的信号转导通路,其异常激活或抑制可能引发如阿尔茨海默氏症、前列腺癌等疾病[1].Raf1蛋白激酶是MAPK信号通路中的一个重要的丝氨酸/苏氨酸特异性蛋白激酶.
The multidrug resistance 1 (MDR1) gene product P-glycoprotein is an ATP-dependent efflux pump associated with chemotherapy failure in breast cancer.In the present study,we show that paclitaxel induces
Craniofacial malformations are common structural birth defects and usually associate with abnormal development of pharyngeal arches.Although some microRNAs (miRNAs) have been found to be implicated in
The tumor microenvironment could induce macrophages differentiation into Tumor-associated macrophages (TAM),which play an important role in the development of tumor inflammation.
VEGFa creates new vessels in embryonic development and organogenesis.Tumors produce a lot of VEGFa to adapt local vasculature for their progression and metastasis,thus anti-angiogenesis therapies,like
Primary cilia,which emanate from the cell surface,exhibit assembly and disassembly dynamics along the progression of cell cycle.However,the mechanism that links ciliary dynamics and cell cycle regulat
The most favored vascular access for hemodialysis of patients with chronic kidney disease(CKD) is an arteriovenous fistula (AVF).Failure of an AVF occurs mainly because of vascular stenosis which refl