【摘 要】
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Recently, genome-wide association studies (GWAS), meta-analyses, and replication studies focusing on bipolar disorder (BD) have implicated the α-1C subunit
【机 构】
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DepartmentofBiochemistryandMolecularBiology,Xi'anJiaotongUniversityHealthScienceCenter,Xi'an,Shaan
论文部分内容阅读
Recently, genome-wide association studies (GWAS), meta-analyses, and replication studies focusing on bipolar disorder (BD) have implicated the α-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) and ankyrin 3 (ANK3) genes in BD.Based on the hypothesis that both schizophrenia (SZ) and BD may share some common genetic risk factors, we investigated the association of CACNA1C and ANK3 withSZ using meta-analytic techniques, combining all published data up to May 2015.Nine teams, including four European decent samples and five Asian sample, contributed 14,141 cases and 30,679 controls for the analysis of CACNA1C rs1006737 and SZ.
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