【摘 要】
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Background To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and coronary heart disease,and the influence ofApoE gene polymorphism on the atorvastatin lipid-lowering effect
【机 构】
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First Affiliated Hospital of Soochow University,Jiangsu,China
【出 处】
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第十二届中国介入心脏病学大会(CIT2014)
论文部分内容阅读
Background To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and coronary heart disease,and the influence ofApoE gene polymorphism on the atorvastatin lipid-lowering effect.Methods Thirty-eoght patients with coronary heart disease (CHD group) hospitalized in cardiovascular department of First Affiliated Hospital of Suzhou University from September 2012 to January 2013 and 30 non-CHD person (control group) were chosen to take part in this research.The multiplex amplification refractory mutation system PCR method was used to detect the ApoE gene polymorphism of the 68 objects,CHD group before and after taking atorvastatin 12 weeks were fasting 12 hours to take forearm venous blood,test serum lipids level.To compare the differences of ApoE polymorphism between the CHD group and control group,and the differences in statin effect after taking the same doze of atorvastatin among different genotypes with CHD.
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