To develop into a functionally normal egg,the fully-grown oocyte(FGO)must resume and complete the first meiosis.Meiotic progression in oocytes is under strict control,when going awry,it will lead to the generation of low quality oocytes that are frequently associated with the major reproductive diseases,e.g.,miscarriage and birth defects.Although much has been learned,the precise mechanisms govening oocyte meiotic progression still remains largely elusive.