Construction of stimuli-responsive controlled release system for targeted drug delivery to specific cells is essentially important for cancer therapy since most chemotherapeutics are severely toxic [1].Surface-functionalized magnetic nanoparticles(MNPs)and end-capped mesoporous silica nanoparticles(MSNs)presented themselves as ideal stimuli-responsive carriers for controlled drug and/or gene delivery,owing to their good biocompatibility,tunable sizes and large surface areas.To trigger drug release via signals derived from cells and to confirm the biosaftey of MSNs-based system attracted much attention in the related field.