【摘 要】
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Spirooxindoles derivatives are one of the most common skeletons found in natural products.[1] Beacause of their unique structure property that two rings joined at a single carbon,[2] and their extensi
【机 构】
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College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou,Henan 450052,China
【出 处】
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中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Spirooxindoles derivatives are one of the most common skeletons found in natural products.[1] Beacause of their unique structure property that two rings joined at a single carbon,[2] and their extensive array of biological activities and pharmacological properties[3],the synthesis of this kind of compounds has been long-standing challenge in organic chemistry,and considerable effort has been devoted to developing efficient and selective synthetic methods to access substituted spirooxindoles.[4] Herein,we report an efficient method through the Michael addition/Friedel-Crafts reaction of α-hydroxyacetophenone to β,γ-Unsaturated α-ketoamides for the synthesis of spirooxindoles.
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