【摘 要】
：
Drug relapse is a major clinical problem mainly caused by maladaptive drug memory.Disruption of drug memory would reduce relapse susceptibility.In this stud
【机 构】
：
复旦大学基础医学院药理研究中心,上海 200032
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
论文部分内容阅读
Drug relapse is a major clinical problem mainly caused by maladaptive drug memory.Disruption of drug memory would reduce relapse susceptibility.In this study,we used drug retrieval procedure to investigate the role of β-adrenergic receptor (β-AR) in addiction memory reconsolidation.Rats were injected propranolol (β-AR antagonist),betaxolol (β1-AR antagonist),ICI-118,551 HCl (β2-AR antagonist) immediately after drug memory retrieval with self-administration of cocaine (3mg/kg).
其他文献
Background:The arcuate nucleus (ARC) of hypothalamus plays a key role in pain processing.Although it is well known that inhibition of NMDA receptor in ARC a
Both dietary and genetic factors contribute to individual differences in body weight regulation.The present study examined the change of sucrose sensitivity
研究开发安全有效的蛋白作为结合疫苗的载体,具有非常重要的意义。一方面可以解决载体多样化的问题。另一方面TT作为多糖结合疫苗的蛋白载体有许多弊端,急需开发新型的蛋白载
Background:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bloating in association with altered bow
第一部分急性高眼压后大鼠视网膜内突触标记蛋白的表达变化 目的：通过观察突触囊泡素(SYN)、囊泡性谷氨酸转运体1(VGLUT1)和蛋白激酶Cα(PKCα)的表达变化，初步了解急性眼高
In the milk-ejection reflex during lactation,activation of hypothalamic neurosecretory oxytocin neurons in the supraoptic and paraventricular nuclei is esse
Scorpion venom heat-resistant peptide (SVHRP) is a component purified from Buthus martensii Karsch scorpion venom.Although scorpions and their venom have be
Androgens such as testosterone play an important role in stabilizing birdsong.The robust nucleus of the arcopallium (RA) is an important pre-motor nucleus c
Objective:Neuropathic pain is an intractable disease.Its pathogenesis is associated with the abnormalities of gene transcription and translation in the sens
阿尔茨海默病(Alzheimers disease,AD)的发生机制至今不完全清楚,其典型的病理特征是脑内出现高密度的以淀粉样β 蛋白(Amyloid β protein,Aβ)为核心的老年斑.随着Aβ