We present a novel platform for noninvasive transmural cardiac electrophysiological imaging (NTCEI),which combines body-surface electrocardiographic data and image-derived anatomic data to compute subject-specific electrophysiological dynamics and electroanatomic substrates not only on heart surfaces but along the depth of the myocardium.Initial success on real-data experiments include 1) transmural scar quantification for patients withprevious history of myocardial infarction;2) trasnmural EP and scar imaging for patients with ventricular arrhythmia;and 3) transmural EP and scar imaging on porcine hearts with chronic infarction.These experiments demonstrated the potentials in computing transmural EP anomalies using only noninvasive observations and without any conditionspecific knowledge a priori,which could not be achieved with either current EP mapping or structural imaging techniques alone.We will also briefly discuss development towards hardware realizations and clinical feasibility.