论文部分内容阅读
Besides their natural role as carriers for genetic information,DNA molecules have been demonstrated to be the most fascinating materials for the construction of a variety of different DNA nanostructures through highly specific Watson-Crick base pairing.The formation of the DNA nanostructures commonly involves self-assembly of multiple sequences into predesigned structures with the presence of sequence-specific nucleic acid triggers.The extent of growth of the DNA nanostructures is heavily dependent upon the amount of the triggers involved,which offers great potentials as signal amplification means for sensitive detection of the triggers.Here,we show how this type of target-triggered assembly/disassembly of DNA nanostructures can serve as significant signal amplification platforms for the detection of small molecules,DNA and microRNA targets.