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The appearance of antibiotic resistance caused by metallo-β-lactamases(MβLs)is a global public health threat due to their rapid spread.
Triazolylthioacetamides as efficient inhibitors of Imipenemase 1(IMP-1)
【摘 要】
：
The appearance of antibiotic resistance caused by metallo-β-lactamases(MβLs)is a global public health threat due to their rapid spread.
【机 构】
：
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,Chemi
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
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The continued emergence of drug-resistant pathogens is a global public health problem.With the increasing antibiotic resistance of bacteria,there is an obvious need for alternative therapeutics and ma
Drug-resistant bacteria pose an urgent public-health crisis.Over the years,β-lactams were the antibiotics of choice for treatment of S.aureus infections1.
β-Lactam antibiotics are widely used in the treatment of bacterial infections.However,The overuse of antibiotics leads to the emergence of drug-resistant bacteria,which has posed a great threat to hum
The drug-resistant bacteria have been a serious threat to the clinical treatment.These bacteria hydrolyze almost all β-lactam antibiotics by expressing the metallo-β-lactamses(MβLs).
The facile dissemination of genes encoding β-lactamase,enzymes capable of hydrolyzing β-lactms,is the important mechanism in antibiotic resistance.