Prodrug相关论文
本文在对比中美两国对于前药专利侵权判定司法实践的基础上,分析了中美两国有关专利共同侵权和诱导侵权的判定规则,借鉴美国法院对......
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为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Advances in Nucleotide Antiviral Development from Scientific Discovery to Clinical Applications:Teno
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phos
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via d
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Design, synthesis and in vitro evaluation of mono (2, 2, 2-trifluoroethyl) esters, mono L-amino acid
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Prednisolone succinate-glucosamine conjugate: Synthesis, characterization and in vitro cellular upta
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
[目的]合成具有pH敏感、缓释特性的壳聚糖-地塞米松前药,通过透析法制备前药胶束纳米粒子.[方法]通过缩合反应将壳聚糖与地塞米松......
Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via d
To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluoroura......
Antibody-directed enzyme prodrug therapy(ADEPT) is a new strategy for the treatment of cancer that has arisen in recent ......
Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phos
A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV act......
Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with disease progression as well a......
Design, synthesis and in vitro evaluation of mono (2, 2, 2-trifluoroethyl) esters, mono L-amino acid
A series of novel mono (2,2,2-trifluoroethyl) esters, mono L-amino acid ester prodrugs of acyclic nucleoside phosphonate......
The curcumin prodrugs, which could be selectively activated in tumor cells, were prepared to establish a basis for the t......
Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PE......
Novel water-soluble prodrugs of combretastatin A-4 (5-8) were synthesized and evaluated for their in vitro cytotoxicity ......
16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bio......
Prednisolone succinate-glucosamine conjugate: Synthesis, characterization and in vitro cellular upta
Prednisolone succinate-glucosamine (PSG) conjugate,a prodrug for prednisolone,was synthesized and confirmed by NMR and M......
目的：合成具有较强抗乙型肝炎病毒（HBV）活性与较高口服吸收性的非环核苷膦酸双L-氨基酸酯衍生物（8a．d）。方法：以2-氯乙醇为原料，通过与多聚......
前药设计已成为药物发展的一个重要方向，前药能够改善药物的油水分配系数，减少药物的代谢，提高靶向性等，因而日益受到重视。本文综述了......
姜黄素前药的研究现状及进展，主要包括聚乙二醇（PEG）负载前药、胆固醇等细胞膜成分负载前药、表面活性剂样两亲分子负载前药、RNA片段......
目的寻找活性更强、副作用更小的烟酸前体药物.方法以烟酸为起始原料,采用酰氯法,通过酯键或酰胺键,分别与对乙酰氨基酚、香草醛、......
为了提高抗肿瘤药物喜树碱的靶向作用,设计并合成了一种喜树碱的环磷酸酯前药。以间氯苯乙酮为起始原料,经过缩合、还原反应,制备......
目的研究布洛芬丁香酚酯微乳剂的抗溃疡作用及其在大鼠体内的药动学。方法采用显微镜法考察布洛芬丁香酚酯微乳的抗溃疡作用。大鼠......
目的探讨以葡聚糖(平均分子量26万)为载体的地塞米松前体药在大鼠胃肠道内的转释特性。方法前体药按5 μmol*kg-1地塞米松(Dex)给......
目的研究含N-乙基-2-甲基-5-硝基咪唑的诺氟沙星、环丙沙星和依诺沙星衍生物的合成及其抗菌活性.方法用含2-甲基-5-硝基咪唑的诺氟......
采用HPLC法测定N1-羧酰-5-氟尿嘧啶系列前体药物在不同pH磷酸盐缓冲溶液中、不同的组织匀浆中的含量以考察降解情况,并数学拟合求......
L-DOPA has gained widespread credit over the past decades as being the mainstay of the pharmacological treatment of Park......
目的研究N-乙基-2-甲基-5-硝基咪唑的环丙氟哌酸及其酯的衍生物的合成.方法采用2-甲基-5-硝基咪唑、环丙氟哌酸等物质为原料,通过......
雷公藤甲素(TL)是从卫矛科雷公藤中提取的环氧二萜内酯,具有显著的抗炎和免疫抑制活性,但TL本身毒性较大、水溶性差、治疗窗窄,极......
特异性地杀伤肿瘤细胞并降低对正常细胞的毒副作用是各种导向治疗方法的共同目标.本文综述了前体药物疗法、免疫毒素、基因疗法、......
恶性肿瘤是影响人类生命健康的重大疾病,传统的化疗药在临床中有着广泛的应用,但是化疗药物通常缺乏靶向性,对于正常组织也有较大......
利用肝素前体K5多糖,通过腙键（Hydrazone bond）连接抗肿瘤药物阿霉素（DOX）,制备具有pH敏感性的K5-hydrazone-DOX（KHD）前体药物。对其载药......
综述了近年来前药的发展状况,并评价了各类前药的特点和发展前景.前药技术作为一种可靠的口服结肠靶向释药系统,不仅能减少药物的......
为寻找新的大豆异黄酮前药，采用建立的生物样品中药物浓度测定的液相色谱法对新型大豆异黄酮染料木素磺酸酯（GBS）进行前药判定以及大......
人体角膜难以吸收分子量较大的药物分子,为了减少高毒药物治疗眼表疾病时经角膜吸收导致的眼内副作用,设计了丝裂霉素C的L-聚谷氨......
目的设计合成具有人体胆酸转运体结合活性的肝靶向前体药物.方法运用活泼酯法原理,设计合成新化合物胆酸拉米夫定酰胺,使用1H-NMR......
枝菌酸是结核分枝杆菌细胞壁组分之一。异烟肼作用的主要靶标是参与枝菌酸生物合成的蛋白质。临床分离耐药株多数在KatG蛋白发生点......
溃疡性结肠炎是一种常见的消化系统疾病,治疗难度大,病变范围广泛、病情反复,在我国发病率逐年增高;另一方面,现有的口服治疗溃疡......
