【摘 要】
：
Surface-enhanced Raman spectroscopy(SERS)can provide whole-organism fingerprint information of microorganism and their sensitive biochemical responses to va
【机 构】
：
KeyLaboratoryofUrbanPollutantConversion,InstituteofUrbanEnvironment,ChineseAcademyofSciences,Xiamen3
【出 处】
：
2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
Surface-enhanced Raman spectroscopy(SERS)can provide whole-organism fingerprint information of microorganism and their sensitive biochemical responses to various environmental factors.The strong electromagnetic enhancement provided by Ag or Au nanoparticles endows SERS extra advantages including ultrahigh sensitivity,rapid,and surface information characterization.Here,the applicability of SERS in studying heavy metal-mediated antibiotic resistance,nanotoxicity of Ag and ZnO NPs to bacteria,as well as variation of bacterial species and chemical compositions of biofilm will be presented.Antibiotic resistance of bacteria poses a threat to global public health.Independent and robust SERS spectral changes representing phenotypic bacterial responses,combined with multivariate analysis,identified that As(V)enhanced antibiotic resistance to tetracycline(Tet).1 For nanotoxicity studies,SERS revealed size-,media-,time-,and does-dependent toxic responses of bacteria to Ag and ZnO nanoparticles.2,3 For biofilm studies,SERS indicated a dynamic change of dominant bacterial species within the biofilm with culture time,based on the distinguishable SERS features of two bacteria.4 SERS also achieved layer-by-layer interrogation of the chemical composition of biofilm on nanofiltration membrane(biofouling)during both development and removal processes and revealed biofilm composition-dependent cleaning efficiency.
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