Total Synthesis of the Proposed Structure of Coibamide A

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：jldxxys

【摘要】

：

Coibamide A is a highly N-methylated cyclodepsipeptides,which was isolated by McPhail and co-workers from a Panamanian marine cyanobacterium in 2007.[1] Coibamide A exhibited attractive low-nanomolar

【作者】

：

LIJING FANG GUIYANG YAO ZHENGYIN PAN WEI WANG WU SU

【机构】

：

Guangdong Key Laboratory of Nanomedicine,Institute of Biomedicine and Biotechnology,Shenzhen Institu

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Coibamide A Cyclodepsipeptide Solid-phase peptide synthesis Aryl hy drazide resi

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　　Coibamide A is a highly N-methylated cyclodepsipeptides,which was isolated by McPhail and co-workers from a Panamanian marine cyanobacterium in 2007.[1] Coibamide A exhibited attractive low-nanomolar inhibitory activities against the proliferation of a number of human cell lines,with a potentially new mechanism of action.

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Total Synthesis of the Proposed Structure of Coibamide A

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