【摘 要】
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Objective:collagen Ⅱ has emerged in recent years as amajor antigen in human RA.A specific CD4+ T cell response to peptides derived from collagen Ⅱ has been found in patients with RA.There is evidence
【机 构】
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Institute of Immunology PLA, Third Military Medical University, Shapingba, Chongqing, P.R.China 4000
【出 处】
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全军免疫学第七届学术交流会暨免疫学新进展主题论坛
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Objective:collagen Ⅱ has emerged in recent years as amajor antigen in human RA.A specific CD4+ T cell response to peptides derived from collagen Ⅱ has been found in patients with RA.There is evidence shows that CD8+ T cells contribute to the initiation,progression and regulation of several pathogenic autoimmune responses.A CD8+T cells response to collagen Ⅱ derived peptides has not yet been investigated.In the present study,we aimed to identify HLA-A*0201-restricted human collagen Ⅱ epitopes,which elicit CD8+ CTL responses probably involving in the immunopathology of human RA.
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