【摘 要】
：
There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade,which is closely correlated with is
【机 构】
：
南京医科大学附属南京医院、附属脑科医院
论文部分内容阅读
There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade,which is closely correlated with ischemic insult occurrence.Our previous studies demonstrated that the Ang-(1-7),was an active member of the brain RAS.
其他文献
目的:分析眩晕/头晕常见病因及相关疾病的临床特征.方法:对392例主诉眩晕/头晕患者,根据详细病史、临床特征、体征以及头颅CT/MRI及MRA,颈椎X线等检查结果,分析病因,总结临床特征.结果:392例眩晕/头晕患者中,椎基底动脉供血不足伴寰枢关节紊乱者或椎间孔狭窄者有97例,占24.7％.
Some new recognitions of pathologic feature of AD patients have provided new important clues about the mechanisms of neuronal apoptosis which make us to see new prospect of AD therapy.Accumulating dat
Background:Microglia/macrophages are known to play important roles in initiating brain inflammation after intracerebral hemorrhage (ICH).LAP3,leucine aminopeptidase 3,has been proven to be expressed b
α B-crystallin (αBC) involves in diverse cellular activities.Previous studies demonstrated that αBC has anti-apoptotic and proliferation promoting effects in multiple diseases.Here we explored a BCs r
目的:紧张与焦虑的发病是生物、心理与社会环境诸多方面因素参与的结果.越来越多的研究显示炎症会导致紧张与焦虑的发生,并提出了炎症假说.课题组在前期得实验已经发现在紧张焦虑的动物模型上,通过RT-PCR,ELISA发现小鼠海马的海马和皮质部位TNF-@,IL-6等炎症因子水平叫对照组明显增高.曾经文献报道过海马是对紧张焦虑反应最敏感的部位,但是神经元的凋亡却首先发生在小鼠的皮质部位,而不是海马,并且文
Aims:To clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors.
Background:Neuroinflammation plays an important role in the pathogenesis of many neurodegenerative diseases and neuronal apoptosis has been reported as one of the most crucial events in the process of
目的:抑郁症"突触发生假说"(synaptogenic hypothesis)认为突触功能障碍和抑郁症发生有关.本研究通过运用透射电镜技术观察海马结构中Grey Ⅰ型兴奋性突触形态学改变,为抑郁症"突触发生障碍"假说提供直接的形态学证据.
目的:研究认知正常老年人群不同APOE基因型静息态海马相关记忆网络分布特征,探索APOE基因多态性调控阿尔茨海默病发病风险的神经机制.方法:对129名认知正常老年受试者(ε2携带组36名,ε3纯合子组44名,ε4携带组49名)完成一般资料收集、多维度认知神经心理评估与静息态功能磁共振扫描.采用AFNI软件预处理影像数据并标准化至MNI空间.
目的:败血症及其并发症是导致重症监护区患者死亡的一个主要疾病,约占ICU死亡率的10-50％.由败血症引起的炎症级联反应导致多器官衰竭直至死亡,其中包括败血症脑病.寄居于中枢神经系统的小胶质细胞内固有免疫信号通路的激活不仅见于感染,而且在脑损伤和慢性疾病中也常见.小胶质细胞前体细胞的激活及寄居的小胶质细胞的过度活化需要被抑制,从而避免对脑组织的过度破坏.寻找能够维持小胶质细胞保持静息或活化状态的关