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Angiotensin-(1-5)[Ang-(1-5)],which is a metabolite of Angiotensin-(1-7)[Ang-(1-7)] catalyzed by angiotensin-converting enzyme(ACE),is a novel vasoactive pentapeptide of the renin-angiotensin system(RAS).Our lab had reported that Ang-(1-7)and Ang-(1-9)had positive effect to the secretion of atrial natriuretic peptide(ANP)via Mas receptor(Mas R)and Ang Ⅱ type 2 receptor(AT2R),respectively.