【摘 要】
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Background: Aberrant DNA methylation plays a significant role in tumorigenesis which can be induced by folate deficiency of diet in colorectal cancer (CRC).
【机 构】
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第二军医大学基础部医学遗传学教研室 上海200433
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Background: Aberrant DNA methylation plays a significant role in tumorigenesis which can be induced by folate deficiency of diet in colorectal cancer (CRC).Some DNA methylation alterations can be reflected in cell-free circulating DNA (circDNA) ,making circDNA an ideal noninvasive biomarker for cancer diagnosis and prognosis.However, what DNA methylation alterations is induced by folate deficiency exactly and whether these alterations is a valid noninvasive circulating biomarker for CRC are still unclear.
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