【摘 要】
：
There is cumulative evidence that the serine-threonine kinase Akt and its downstream nuclear transcription factor CREB are involved in neuronal survival and protection.The Akt activates and phosphoryl
【机 构】
：
Department of Neurology,Second Hospital of Hebei Medical University
论文部分内容阅读
There is cumulative evidence that the serine-threonine kinase Akt and its downstream nuclear transcription factor CREB are involved in neuronal survival and protection.The Akt activates and phosphorylates CREB at Ser133,resulting in the up-regulation of pro-survival CREB target genes such as BDNF and Bcl-2.Thus,Akt/CREB signaling pathway may be one propitious target for treatment of ischemic cerebral injury.Nobiletin (NOB) exhibits a wide spectrum of beneficial biological properties including anti-inflammatory,antioxidant,anti-carcinogenic actions and contributes to reverse learning impairment in Alzheimers disease rat.
其他文献
目的 实施农村社区强化卒中健康教育,并评价其实施效果.方法 2012年1月至2012年12月,我们在江苏省赣榆县的3个乡镇实施农村社区强化卒中健康教育,并以相邻非实施社区为对照,分析随访一年前后的卒中知晓率、发病3小时内就诊率、溶栓率、致残率、死亡率等指标的变化.结果 干预后强化教育组的卒中知晓率由干预前的42.86％提升到干预后的82.18％,差异显著(X2=2.213E4 p=0.000),而
目的 探讨反馈式功能性电刺激治疗对脑卒中后上肢运动功能恢复的影响及其fMRI机制.方法 21例脑卒中患者随机分为反馈式功能性电刺激组(实验1组)8人,功能性电刺激组(实验2组)7人,对照组6人,三组患者均进行常规神经内科药物治疗和康复治疗,实验1组进行反馈式功能性电刺激治疗,实验2组行功能性电刺激治疗,疗程4周.治疗前后行FugI-Meyer上肢评分,腕背伸角度,fMRI进行脑M1区激活强度检查.
目的 缺血性中风严重危害人类健康,随着对该病的临床观察与实践总结,逐渐形成了缺血性中风"毒损脑络"的病机假说.通络救脑注射液是针对缺血性脑卒中"毒损脑络"病机研发的现代注射剂.缺血激活的小胶质细胞不仅释放炎症因子促进神经元死亡,还分泌了神经保护性因子.平衡其所释放神经毒性因子跟神经保护因子的平衡是小胶质细胞功能稳定的关键,亦是药物作用调控的关卡.本研究以小胶质细胞为研究对象,对比该注射液及其两个有
Objective To investigate the neuroprotective mechanism of exogenous hydrogen sulfide on rats after cerebral ischemia-reperfusion by ERK-CREB pathway.Methods A total of 180 Sprague-Dawley male rats wer
目的 探讨NINJ2基因多态性与LAA型脑梗死的相关性,并初步探讨遗传因素对动脉粥样硬化血管床选择性损害的影响.方法 采用病例对照研究,选取286例LAA型脑梗死患者和298例同期非脑梗死人群,选取NINJ2基因4个代表性单核酸多态性[rs11833579 (G/A)、rs12425791 (G/A)、rs10849373 (G/A)和rs 11063806(G/A)],应用聚合酶链反应限制性片段
Oxidative damage plays a detrimental role in the pathophysiology of cerebral ischemia and may represent a therapeutic target.The transcription factor nuclear factor erythroid 2-related factor 2(Nrf2)
Stroke has a high incidence in the elderly.Stroke enters the chronic phase 3 months after initial stroke onset.Currently,there is no pharmaceutical treatment available for chronic stroke.We have demon
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke.Shikonin has gained attention for its prominent anti-inflammatory prop
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.Parthenolide (PN) has been proved to elicit a wide range of biological activities
Gamma-secretase inhibitor,N-[N-(3,5-difluor-ophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling,which is recognized as the cell fate signaling an