Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves cleavage of amyloid precursor protein(APP)by γ-secretase,a protease known to cleav
Objective Lots of studies showed high frequency electro-acupuncture(EA)stimulation alleviated motor symptoms of parkinsons disease(PD)patients and animal models,but the mechanisms were unclear.
Alzheimers disease(AD)mainly involves damage to the central nervous system,which clinical manifestation is reduced learning and memory,mood change and cognitive dysfunction.
Brain derived neurotrophic factor(BDNF)has been known to play an important role in various mental disorders or diseases such as Alzheimers disease(AD).
Converging lines of evidence demonstrate that intracellular accumulation of α-synuclein(α-Syn)as filamentous aggregates plays a central role in synucleinopathies pathogenesis such as Parkinson disease