【摘 要】
：
Microtubule (MT) stability is related to the hydrolysis of the guanosine triphosphate nucleotide (NT) bound to β-tubulin.However, the molecular mechanism by wh
【机 构】
：
MaxPlanckInstituteforColloidsandInterfaces,TheoryandBiosystems,Germany
【出 处】
：
8th IUPAP International Conference on Biological Physics(第八届
论文部分内容阅读
Microtubule (MT) stability is related to the hydrolysis of the guanosine triphosphate nucleotide (NT) bound to β-tubulin.However, the molecular mechanism by which the NT state influences the stability of the contacts in the MT lattice remains elusive.With large-scale atomistic simulations and a coarse-grained (CG) analysis of the fluctuations, we identify regions of the protein where local changes are induced by the NT state and by the lateral and longitudinal contacts in the aggregates.The CG analysis provides an indication of how the structural changes affect the interaction strength between the proteins.
其他文献
随着信息时代的到来,档案管理作为一个城市、一个单位、一个企业的记忆传承,承担着重要的责任,发挥着巨大的作用.由于档案管理工作长期处于边缘化状态,人员素质偏低,技术落后
It is determinant to understand how cells regulate their shape in order to apprehend the mechanisms underlying tissue morphogenesis during development.Most pola
医学会自成立以来每年均会举办数百次学术会议,积累了诸多档案资料.其中,会议档案是由举办的医学论坛在组织、开展等环节中逐步构成的,主要作用是搭建医学会议数据管理系统,
在城镇住房制度改革深化,不动产统一登记措施的制定和落实的影响下,房产档案信息服务模式和范围发生了巨大的变化,房产档案管理也面临着许多挑战和机遇.rn一、房产登记档案信
In Clathrin-mediated endocytosis, Clathrin assembles into a soccerball-like structure at the plasma membrane, that was proposed to deform the membrane by scaffo
档案科学管理范畴较为广泛,在庞大的档案资料中,承载着分门别类的各个行业有价值的信息、资料.通过科学化地收集、整理,规范化地收藏、管理,能够为社会、为民生提供重要的服
中国高等职业教育在新时代中发展速度非常快,但是规模、体系、质量、文化等方面依然处于探索阶段.高职院校的档案管理应该顺应时代的发展,实现信息化的转变,提升档案管理工作
一、城建档案服务利用概述rn城建档案是对城市建设过程的真实记录,是城市建设的重要信息来源.在当前城市快速发展过程中,城市档案的利用需求增加,迫切需要改善城建档案的服务
A molecular robot is an autonomous system consisting of molecular devices implementing sensors, actuators and computers.It observes its environment by its senso