目的:探讨提高治疗肝癌远期疗效的途径。方法:回顾性分析生存>10年的15例肝癌术后患者临床资料。结果:体检发现亚临床肝癌8例,其中肿瘤直径<5cm的小肝癌6例,行肝脏切除术后生存>11年8个月,其中1例生存已超过18年8个月;肿瘤直径≥10cm的大肝癌4例,行一期肝切除,术后生存10年4个月～14年5个月。不能手术切除5例,先行肝动脉和门静脉栓塞化疗,降期后再二期肝切除术,术后生存11年2个月～16年5个月;其中2例术后复发,分别行再次肝切除术及γ刀治疗,治疗后累计生存期分别超过12年2个月和14年7个月。1例术后6年5个月发生门脉高压引起胃底静脉破裂出血,行贲门周围离断术其生存超过12年1个月。结论:早期发现、早期确诊及规范治疗是肝癌长期生存的关键。术后行多学科综合治疗和预防复发的治疗,对复发病灶再手术切除或局部消融治疗,术后并发门脉高压大出血及时手术止血治疗,是提高肝癌生存率的重要途径。 Objective: To explore ways to improve long-term efficacy of treatment of liver cancer. Methods: The clinical data of 15 postoperative patients with liver cancer who survived for more than 10 years were retrospectively analyzed. Results: There were 8 cases of subclinical hepatocellular carcinoma in the physical examination, 6 cases of small hepatocellular carcinoma whose diameter was less than 5 cm and survived more than 11 years and 8 months after hepatectomy, of which 1 case survived for more than 18 years and 8 months; 4 cases of large liver cancer, a one-stage hepatectomy, survival 10 years and 4 months to 14 years and 5 months. In 5 cases, hepatic artery and portal vein embolization chemotherapy were performed first, then hepatectomy was performed after the second phase of hepatic resection. The patients survived for 11 years and 2 months to 16 years and 5 months after operation. Two of them recurred after operation, Resection and γ knife treatment, the cumulative survival after treatment were more than 12 years and 2 months and 14 years and 7 months. One case occurred 6 months and 5 months after portal hypertension caused rupture of gastric fundus, line cardia around the surgery to survive more than 12 years and 1 month. Conclusion: Early detection, early diagnosis and standardized treatment are the keys to the long-term survival of liver cancer. Postoperative multidisciplinary comprehensive treatment and prevention of recurrence of the treatment of recurrent or recurrent resection or local ablation of the treatment of postoperative complications of portal hypertension and timely surgical bleeding is an important way to improve the survival rate of liver cancer.