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Pituitary adenoma,craniopharyngioma, meningioma are common sellar lesions accounting for more than 90％ of sellar tumors.The aim of this study is to assess the reliability and safeness of the lateral supraorbital approach (LSO) to remove sellar tumors.Between June 2011 and December 2011,23 patients with neoplastic lesions underwent surgery by the senior author(Z.W.) with the LSO approach.The clinical presentations,neuroradiological findings,microsurgical techniques,and outcome at discharge of these patients were analyzed.In addition,the clinical series in the English literature were also extensively reviewed.Eleven (48％) patients were treated for pituitary adenoma; 7 (30％) patients for tuberculum sellae meningioma; and 5 (22％) patients for craniopharyngioma.Seemingly complete tumor removal was achieved in 21 patients(91％ ) ;surgical mortality was 4.3％ ( 1 case).Postoperatively,no patients had cerebrospinal fluid leakage or new visual deficits.One (4％)patient had intracranial infection,and 1 (4％) had a postoperative hematoma.The median Karnofsky score at discharge was 87.4 ( range,0-100).The Glasgow outcome scale at discharge was 4.6 ( range,1-5 ).Of all,21 (91.3％) patients achieved favorable outcomes. Sellar tumors can be removed via the LSO approach with relatively low morbidity and mortality.Surgical results with this fast and simple approach are similar to those obtained with more extensive,complex,and time-consuming approaches.