Multidrug resistance is a worldwide problem that has led to clinical chemotherapy failure.The ATP binding cassette(ABC)-transporter P-glycoprotein(MDR1/P-gp)is a well-studied efflux protein that induces multidrug resistance in cancer therapy by pumping drugs out of cancer cells through ATP depletion [1].Paclitaxel(PTX)is an anti-microtubule agent that is successfully applied in clinical therapy.It inhibits the cell mitosis by promoting the polymerization and inhibiting the depolymerization of tubulin to maintain microtubule stability and then makes the cells suspend in G2 and M phase of cell mitosis [2].Phthalocyanine Zinc(ZnPc)is a second-generation photosensitizer applied in PDT,which is a recently emerging promising therapy method exploited in superficial tumors when irradiated with appropriate wavelength of light[3].