The point mutations in the active-site arginine residues of isocitrate dehydrogenase(IDH)(IDH1/R132,IDH2/R140,and IDH2/R172)occur frequently in a variety of
Gastrointestinal stromal tumor(GIST)is the most common sarcoma of the gastrointestinal tract.Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are